Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy.

@article{Gangula1997CalcitoninGP,
  title={Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy.},
  author={Pandu R. R. Gangula and Scott C. Supowit and Sunil Jayalath Wimalawansa and Huawei Zhao and David Michael Hallman and Donald J DiPette and Chandrasekhar Yallampalli},
  journal={Hypertension},
  year={1997},
  volume={29 1 Pt 2},
  pages={
          248-53
        }
}
Inhibition of nitric oxide production with NG-nitro-L-arginine methyl ester (L-NAME) increases blood pressure and fetal mortality in pregnant rats. We previously reported that administration of calcitonin gene-related peptide (CGRP) reduces the blood pressure and fetal death produced by L-NAME. To determine the hemodynamic role of endogenous CGRP in this setting, CGRP8-37, a CGRP receptor antagonist, was used. In addition, CGRP mRNA and peptide levels were determined in dorsal root ganglia. L… CONTINUE READING
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