Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure.

@article{Katori2005CalcitoninGP,
  title={Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure.},
  author={Tatsuo Katori and Donald B. Hoover and Jeffrey L Ardell and Robert H. Helm and Diego F. Belardi and Carlo Gabriele Tocchetti and Paul R. Forfia and David A. Kass and Nazareno Paolocci},
  journal={Circulation research},
  year={2005},
  volume={96 2},
  pages={234-43}
}
Calcitonin gene-related peptide (CGRP) is a nonadrenergic/noncholinergic (NANC) peptide with vasodilatative/inotropic action that may benefit the failing heart. However, precise mechanisms for its in vivo inotropic action remain unclear. To assess this, dogs with normal or failing (sustained tachypacing) hearts were instrumented for pressure-dimension… CONTINUE READING