Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats.

@article{Plourde1997CalcitoninGP,
  title={Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats.},
  author={Victor Plourde and Serge St-Pierre and Re´mi Quirion},
  journal={The American journal of physiology},
  year={1997},
  volume={273 1 Pt 1},
  pages={
          G191-6
        }
}
The role of calcitonin gene-related peptide (CGRP) on colorectal distension-induced visceral pain was investigated in conscious rats. Intracolonic administration of acetic acid (0.6%) resulted in a significantly increased number of abdominal contractions in response to colorectal balloon distension from 5.8 +/- 1.2 in controls to 16.6 +/- 1.0 in acetic acid-treated animals (P < 0.05), evidencing sensitization of visceral afferent pathways and subsequently visceral hyperalgesia. This… CONTINUE READING
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