Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice.

  title={Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice.},
  author={Toshiaki Mishima and Yoshiya Ito and Kanako Hosono and Yukio Tamura and Yasushi Uchida and Mitsuhiro Hirata and Tatsunori Suzsuki and Hideki Amano and Shintaro Kato and Yukiko Kurihara and Hiroki Kurihara and Izumi Hayashi and Masahiko Watanabe and Masataka Majima},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={300 2},
It is known that the neural system plays a fundamental role in neovascularization. A neuropeptide, calcitonin gene-related peptide (CGRP), is widely distributed in the central and peripheral neuronal systems. However, it remains to be elucidated the role of CGRP in angiogenesis during ischemia. The present study examined whether endogenous CGRP released from neuronal systems facilitates revascularization in response to ischemia using CGRP knockout mice (CGRP-/-). CGRP-/- or their wild-type… 

Figures from this paper

Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline

Results indicate endogenous CGRP is protective against ischemia-induced neuronal cell injury and could, thus, be a novel candidate for use in the treatment of both cerebral ischemIA and progression of cognitive decline.

Roles of calcitonin gene-related peptide in ehancement of angiogenesis

Results suggest that sensory nerves facilitate tumor-associated angiogenesis and tumor growth during tumor development via a release of CGRP, which may become a novel therapeutic target for controllingAngiogenesis.

Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases.

Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo

The ability of endogenous and exogenous CGRP to restore blood pressure, when nitric oxide synthesis is blocked, in a model of cardiovascular disease associated with endothelial dysfunction and impaired Nitric oxide production is shown to support the proposal that C GRP provides a novel treatment for cardiovascular disease.

Role for Substance P–Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis During Ischemia in Mice and in Human Subjects

The role of the neuropeptide substance P (SP) and cognate neurokinin 1 (NK1) nociceptor in PC activation and angiogenesis during ischemia in mice and in human subjects is investigated, highlighting the role of SP in reparative neovascularization.

The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects

CGRP has been suggested as a cardioprotective, endogenous mediator released under stress to help preserve cardiovascular function and is discussed on the future of CGRP as a novel target in various cardiovascular diseases.

Calcitonin gene-related peptide: physiology and pathophysiology.

It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from knowledge concerning this molecule.



Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide

Results indicate that endogenous C GRP facilitates tumor-associated angiogenesis and tumor growth and suggest that relevant CGRP may be derived from neuronal systems including primary sensory neurons and may become a therapeutic target for cancers.

Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury.

Data indicate that, in this in vitro setting, deletion of alpha-CGRP makes the heart more vulnerable to I/R injury, possibly due, at least in part, to increased oxidative stress.

Increased Blood Pressure in α-Calcitonin Gene–Related Peptide/Calcitonin Gene Knockout Mice

Results indicate for the first time that α- CGRP may be involved in the long-term regulation of resting BP and suggest that these mice are particularly sensitive to challenges to BP homeostasis because of the loss of a compensatory vasodilator mechanism.

Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice.

Results indicate for the first time that alpha-CGRP may be involved in the long-term regulation of resting BP and suggest that these mice are particularly sensitive to challenges to BP homeostasis because of the loss of a compensatory vasodilator mechanism.

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials.

This work has shown that alternative tissue-specific processing of primary mRNA from the α-CT/CGRP gene in rats generates two distinct peptides, CT and CGRP, which are the most potent endogenous vasodilatory peptides that have been discovered.

Activin Induces Tactile Allodynia and Increases Calcitonin Gene-Related Peptide after Peripheral Inflammation

The hypothesis that inflammation and skin changes involving activin A cause some sensory neurons to increase CGRP expression and pain responses is supported.

Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells.

It is demonstrated that endothelial cells of both elastic and large muscular arteries synthesize C GRP and store it, in part, in WP bodies, implying that CGRP may act as an endothelium-derived relaxing factor in these vessels.

Calcitonin gene-related peptide stimulates proliferation of human endothelial cells.

It is suggested that C GRP may act as a local factor stimulating proliferation of endothelial cells; that the mechanism of action is associated with cAMP formation; and that this effect of CGRP may be important for formation of new vessels during physiological and pathophysiological events such as ischemia, inflammation, and wound healing.

Vascular actions of calcitonin gene-related peptide and adrenomedullin.

The receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin are summarized, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed.

Elevated Sympathetic Nervous Activity in Mice Deficient in &agr;CGRP

It is suggested that &agr;CGRP contributes to the regulation of cardiovascular function through inhibitory modulation of sympathetic nervous activity through inhibition of atropine and/or atenolol.