Calcitonin gene-related peptide erases the fear memory and facilitates long-term potentiation in the central nucleus of the amygdala in rats.

@article{Wu2015CalcitoninGP,
  title={Calcitonin gene-related peptide erases the fear memory and facilitates long-term potentiation in the central nucleus of the amygdala in rats.},
  author={Xin Wu and Jie-Ting Zhang and Jue Liu and Si Hyung Yang and Tao Chen and Jian-guo Chen and Fang Wang},
  journal={Journal of neurochemistry},
  year={2015},
  volume={135 4},
  pages={787-98}
}
Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide, which plays a critical role in the central nervous system. CGRP binds to G protein-coupled receptors, including CGRP1, which couples positively to adenylyl cyclase (AC) and protein kinase A (PKA) activation. CGRP and CGRP1 receptors are enriched in central nucleus of the amygdala (CeA), the main part of the amygdala, which regulates conditioned fear memories. Here, we reported the importance of CGRP and CGRP1 receptor for… CONTINUE READING
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