Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions.

@article{Kloot1998CalcitoninGP,
  title={Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions.},
  author={William G. Van der Kloot and W B Benjamin and Olga P. Balezina},
  journal={The Journal of physiology},
  year={1998},
  volume={507 ( Pt 3)},
  pages={689-95}
}
1. Calcitonin gene-related peptide (CGRP) is found in dense-cored vesicles in the motor nerve terminal. 2. Exogenous CGRP increased the size of the quanta. The increase in size reached a maximum after about 40 min. The lowest effective concentration of human CGRP (hCGRP) was 0.8 nM. The action of hCGRP was antagonized by (-)-vesamicol, a drug that blocks active acetylcholine (ACh) uptake into synaptic vesicles, so it appears that hCGRP increases size by adding more ACh to the quanta. The action… CONTINUE READING