Calcitonin gene-related peptide (human alpha-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage.

@article{Juul1994CalcitoninGP,
  title={Calcitonin gene-related peptide (human alpha-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage.},
  author={Roar Juul and Svend Aakhus and K Bjoernstad and Sven Erik Gisvold and Alf O. Brubakk and Lars Edvinsson},
  journal={Neuroscience letters},
  year={1994},
  volume={170 1},
  pages={67-70}
}
Calcitonin gene-related peptide (CGRP) is a neuropeptide co-stored with tachykinins (substance P, neurokinin A) in cerebrovascular sensory fibers in the trigeminal ganglion. Preceding studies on subarachnoid hemorrhage (SAH) revealed that an enhanced release of CGRP resulted in the selective loss of perivascular CGRP. Therefore, the present study was designed to evaluate the effects of intravenous administration of human alpha-CGRP on cerebral vasoconstriction in the postoperative course after… CONTINUE READING