Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs.

@article{Tach1984CalcitoninGP,
  title={Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs.},
  author={Yvette F. Tach{\'e} and Theodore N. Pappas and M Lauffenburger and Yoshiaki Goto and John H. Walsh and Haile T. Debas},
  journal={Gastroenterology},
  year={1984},
  volume={87 2},
  pages={344-9}
}
Calcitonin gene-related peptide is a 37-residue peptide recently characterized in central and peripheral nervous system. The pharmacologic or physiologic importance of this peptide is not known. We studied the effect of calcitonin gene-related peptide on exogenously stimulated gastric acid secretion (pentagastrin, histamine, bethanechol, and intracisternal thyrotropin-releasing hormone) in the urethane-anesthetized rat. Calcitonin gene-related peptide (2.6 nmol/kg X h) caused a 63%-78… CONTINUE READING

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