Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle

@article{PedersenBjergaard1991CalcitoninGP,
  title={Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle},
  author={Ulrik Pedersen-Bjergaard and Lars B{\o}geskov Nielsen and Kai Arne Jensen and Lars Edvinsson and Jes Olesen},
  journal={Peptides},
  year={1991},
  volume={12},
  pages={333-337}
}
Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the forearm skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation… CONTINUE READING

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