Calcitonin gene–related peptide inhibits Langerhans cell–mediated HIV-1 transmission

  title={Calcitonin gene–related peptide inhibits Langerhans cell–mediated HIV-1 transmission},
  author={Yonatan Ganor and Anne-Sophie Drillet-Dangeard and L Lopalco and Dot Tudor and Giuseppe Tambussi and Nicolas Barry Delongchamps and Marc Zerbib and Morgane Bomsel},
  booktitle={The Journal of experimental medicine},
Upon its mucosal entry, human immunodeficiency virus type 1 (HIV-1) is internalized by Langerhans cells (LCs) in stratified epithelia and transferred locally to T cells. In such epithelia, LCs are in direct contact with peripheral neurons secreting calcitonin gene-related peptide (CGRP). Although CGRP has immunomodulatory effects on LC functions, its potential influence on the interactions between LCs and HIV-1 is unknown. We show that CGRP acts via its receptor expressed by LCs and interferes… CONTINUE READING
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