Calcitonin gene‐related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions

  title={Calcitonin gene‐related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions},
  author={W. Kloot and William B. Benjamin and Olga P. Balezina},
  journal={The Journal of Physiology},
  • W. Kloot, William B. Benjamin, Olga P. Balezina
  • Published 1998
  • Chemistry, Medicine
  • The Journal of Physiology
  • 1 Calcitonin gene‐related peptide (CGRP) is found in dense‐cored vesicles in the motor nerve terminal. 2 Exogenous CGRP increased the size of the quanta. The increase in size reached a maximum after about 40 min. The lowest effective concentration of human CGRP (hCGRP) was 0.8 nM. The action of hCGRP was antagonized by (−)‐vesamicol, a drug that blocks active acetylcholine (ACh) uptake into synaptic vesicles, so it appears that hCGRP increases size by adding more ACh to the quanta. The action… CONTINUE READING
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