Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations

@article{Xie2020CalcitoninAB,
  title={Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations},
  author={Jing-Bo Xie and Jian Guo and Zaeema Kanwal and Mingzheng Wu and Xiangyang Lv and Nihal Abdalla Ibrahim and Ping Li and Manal Ali Buabeid and El‐Shaimaa A. Arafa and Qingshan Sun},
  journal={International Journal of Endocrinology},
  year={2020},
  volume={2020}
}
Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone. Thus, calcitonin was said as a primary regulator of the bone resorption process. This is the reason why calcitonin has been used widely in clinics for the treatment of bone disorders such as osteoporosis, hypercalcemia, and Paget's… 

Figures from this paper

Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases.
Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division
TLDR
It is found that ADM provoked a significant stimulation in osteoclastogenesis only in the presence of calcitonin; a similar biological effect was seen with mAbKat1 in the bone marrow culture system.
The Development of Molecular Biology of Osteoporosis
TLDR
This article has focused on molecules that are produced by osteoblasts, osteocytes, and osteoclasts and their mechanism of action on these cells and their mechanisms of action target different molecular aspects of these bone cells to minimize osteoporosis.
The emerging role of phosphorus in human health.
Hypercalcemia in Children Using the Ketogenic Diet: A Multicenter Study.
TLDR
Ketotic hypercalcemia can occur years after starting the ketogenic diet, especially in the setting of renal impairment, and appears to be due to reduced osteoblast activity and impaired bone formation.
The Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology
TLDR
This review will focus on the various countermeasures currently in place or proposed to address bone loss in conditions of microgravity, analyzing in detail the advantages and disadvantages of each option from a pharmacological point of view.
Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery
TLDR
This review summarizes the relevant available data related to LT4 suppressive treatment and the associated risk of cardiac arrhythmia.
Bone remodeling stages under physiological conditions and glucocorticoid in excess: Focus on cellular and molecular mechanisms
Kyiv City Clinical Emergency Hospital, Bratyslavska st. 3, Kyiv, 02660, Ukraine. Tel.: +38-044-527-69-08. E-mail:bsmp@health.kiev.ua Povoroznyuk, V. V., Dedukh, N. V., Bystrytska, M. A., &
Identification and Functional Annotation of Genes Related to Bone Stability in Laying Hens Using Random Forests
TLDR
The assumption that multiple genes determine bone strength, with each of them having a rather small effect, can be supported, and the genes reported here are promising in terms of alleviating bone disorders in laying hens.
Dynamic Effects of the Third Generation Bisphosphonate of Risedronate on Rat Osteoporotic Fractures for Clinical Usage Guidance
To better understand the risks of bisphosphonates in order to develop guidance for appropriate clinical usage, to compared femoral fracture healing at different time points and to explore the effects
...
1
2
...

References

SHOWING 1-10 OF 248 REFERENCES
Calcitonin: Physiology or fantasy?
  • R. Davey, D. Findlay
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2013
TLDR
Mice in which the CTR is deleted in osteoclasts are more susceptible to induced hypercalcemia and exogenous calcitonin is able to lower serum calcium in younger animals, consistent with the hypothesis that calcitonine can regulate serum calcium by inhibiting the efflux of calcium from bone.
Calcitonin Physiology, Saved by a Lysophospholipid
  • T. Martin, N. Sims
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2015
TLDR
A recent report in Nature Communications provides further impetus to the idea that despite its pharmacologic inhibition of bone resorption, calcitonin also functions physiologically as an inhibitor of bone formation.
Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice
  • R. Davey, A. Turner, J. Zajac
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2008
TLDR
Evidence is provided for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress by generating a viable global CTR knockout mouse model using the Cre/loxP system.
Amylin and adrenomedullin: novel regulators of bone growth.
TLDR
These small peptides, or their analogues, are attractive candidates as anabolic therapies for osteoporosis because they can be retained in peptide fragments of the molecule whilst losing the parent molecule's effects on carbohydrate metabolism or vasodilatory properties respectively.
The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation.
What PROOF proves about calcitonin and clinical trials.
...
1
2
3
4
5
...