Calcitonin alters behaviour of isolated osteoclasts.

  title={Calcitonin alters behaviour of isolated osteoclasts.},
  author={Timothy John Chambers and Christopher J. Magnus},
  journal={The Journal of pathology},
  volume={136 1},
Osteoclasts were incubated on a glass or plastic substrate and the effect of calcitonin (CT) on their behaviour was observed. Before exposure to CT the osteoclasts were actively motile, the cytoplasm advancing behind broad pseudopodial (lamellipodial) processes which showed intense ruffling activity. CT caused cessation of lamellipodial activity within minutes, followed by gradual fragmentation and retraction of lamellipodia. Complete osteoclast quiescence was regularly induced by… CONTINUE READING

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