Calcitonin Receptor Gene Polymorphism in Japanese Women: Correlation with Body Mass and Bone Mineral Density

@article{Nakamura2001CalcitoninRG,
  title={Calcitonin Receptor Gene Polymorphism in Japanese Women: Correlation with Body Mass and Bone Mineral Density},
  author={M. Nakamura and S Morimoto and Z Zhang and Hirotoshi Utsunomiya and T. Inagami and Toshio Ogihara and Kennichi Kakudo},
  journal={Calcified Tissue International},
  year={2001},
  volume={68},
  pages={211-215}
}
We have identified a polymorphism at position 1377 of the calcitonin receptor (CTR) gene which generates CC, CT, or TT genotype. In this study, the genotypes of the CTR and their relationship with the body height, the body weight, the bone mineral density (BMD), and osteocalcin levels were examined in 152 healthy Japanese women aged 16-43 years. The CTR genotypic frequencies in the Japanese population were 77.0% for CC, 20.4% for CT, and 2.6% for TT. The height, BMD, and osteocalcin levels were… 
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The C1377T polymorphism in the CTR gene is associated with BMD at the lumbar spine in a postmenopausal Han Chinese population and the CTR genes may become a useful genetic marker for predicting the risk of developing osteoporosis in post menopausal Chinese women.
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  • Biology, Medicine
    The journal of nutrition, health & aging
  • 2013
TLDR
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TLDR
A significant association of this SNP with periodontitis only in females is revealed and this study highlights the predisposing role of CT genotype and T allele in the causation ofperiodontitis.
The Relationship between Alu I Polymorphisms in the Calcitonin Receptor Gene and Fluorosis Endemic to Chongqing, China
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An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
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It was concluded that most mutations affecting BMD are very old and are common in two or three major ethnic populations, which implies that these BMD-affecting loci are very close to, and are likely to be within, the candidate genes.
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TLDR
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