Calcitonin Receptor Gene Polymorphism in Japanese Women: Correlation with Body Mass and Bone Mineral Density

  title={Calcitonin Receptor Gene Polymorphism in Japanese Women: Correlation with Body Mass and Bone Mineral Density},
  author={M. Nakamura and S Morimoto and Z Zhang and Hirotoshi Utsunomiya and T. Inagami and Toshio Ogihara and Kennichi Kakudo},
  journal={Calcified Tissue International},
We have identified a polymorphism at position 1377 of the calcitonin receptor (CTR) gene which generates CC, CT, or TT genotype. In this study, the genotypes of the CTR and their relationship with the body height, the body weight, the bone mineral density (BMD), and osteocalcin levels were examined in 152 healthy Japanese women aged 16-43 years. The CTR genotypic frequencies in the Japanese population were 77.0% for CC, 20.4% for CT, and 2.6% for TT. The height, BMD, and osteocalcin levels were… 
Association of calcitonin receptor gene polymorphism with bone mineral density in postmenopausal Chinese women: a meta-analysis
The C1377T polymorphism in the CTR gene is associated with BMD at the lumbar spine in a postmenopausal Han Chinese population and the CTR genes may become a useful genetic marker for predicting the risk of developing osteoporosis in post menopausal Chinese women.
Fracture, bone mineral density, and the effects of calcitonin receptor gene in postmenopausal Koreans
Results indicate that the CALCR gene may regulate bone metabolism, and +60644C > T in the CAL CR gene may genetically modulate bone phenotype.
Calcitonin receptor gene polymorphism in Chinese Xinjiang Han and Uygur women with primary osteoporosis
  • J. Xu, Y. Gao, F. Wang
  • Biology, Medicine
    The journal of nutrition, health & aging
  • 2013
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis, suggesting that this CTR gene polymorphism may not affect incidence of osteopOrosis.
Genetic Polymorphisms in Calcitonin Receptor Gene and Risk for Recurrent Kidney Calcium Stone Disease
A potential association between 3′UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease is indicated.
Calcitonin receptor (CTR) gene polymorphism in a Turkish population using PCR-RFLP assay
The Turkish population showed a close similarity with Italian population with regard to genotype and allele frequencies of CTR gene and Frequency of heterozygote genotype, which has been suggested being less prone to osteoporosis, was higher than Japanese and Asian populations.
A significant association of this SNP with periodontitis only in females is revealed and this study highlights the predisposing role of CT genotype and T allele in the causation ofperiodontitis.
The Relationship between Alu I Polymorphisms in the Calcitonin Receptor Gene and Fluorosis Endemic to Chongqing, China
An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
Association Between Bone Mineral Density and Candidate Genes in Different Ethnic Populations and Its Implications
It was concluded that most mutations affecting BMD are very old and are common in two or three major ethnic populations, which implies that these BMD-affecting loci are very close to, and are likely to be within, the candidate genes.
Bone mineral density-affecting genes in Africans.
Allele frequencies of BMD-affecting genes and their association with BMD in Africans were determined in 143 recent immigrants from sub-Saharan Sudan to the United States to play a role in the ethnic diversity in BMD and/or BMC.


Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women.
Evidence of RFLPs at the CTR gene locus in Caucasian postmenopausal women of Italian origin made it possible to identify the involvement of another gene, the CTR genes, in the determination of bone mass.
Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.
It is suggested that polymorphism of CTR could be associated with osteoporotic fractures and BMD in a population of post-menopausal women.
Association of bone mineral density with polymorphism of the estrogen receptor gene
It is suggested that some variation of the ER gene linked to these RFLPs is associated with low BMD and that this at least partly explains the cause of postmenopausal osteoporosis in Japanese women.
Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis.
The results suggest that genetic variation at the ER locus may be associated with some determinants for BMD and bone metabolism in postmenopausal women.
Prediction of bone density from vitamin D receptor alleles
It is shown that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals.
Genetic factors in determining bone mass.
The significantly larger variation in intrapair differences in DZ twins indicates that these traits have significant genetic determinants, which alone or in conjunction with environmental factors may predispose persons to the development of osteoporosis.
Allelic variants of human calcitonin receptor in the Japanese population
Structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid.
Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing.
The gene encoding the calcitonin receptor (CTR) was isolated from a porcine kidney epithelial cell line (LLC-PK1) genomic library and found to span approximately 70 kilobases, and transcription initiation site of the CTR gene was mapped to chromosome band 9q11-q12.
Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction.
The distinct functional characteristics of GC-2 and GC-10 indicate that the first intracellular domain of the CTR plays a previously unidentified role in modulating ligand binding and signal transduction via the G protein/adenylate cyclase system.
Cloning and characterization of an abundant subtype of the human calcitonin receptor.
By using a human/rodent somatic cell hybrid panel and in situ hybridization, the human calcitonin receptor gene was localized to chromosome 7 and the insert-negative cDNA was stably expressed in baby hamster kidney cells.