Calcitonin Gene‐Related Peptide in the Regulation of Cardiac Function a

@article{Goto1992CalcitoninGP,
  title={Calcitonin Gene‐Related Peptide in the Regulation of Cardiac Function a},
  author={Katsutoshi Goto and Takashi Miyauchi and Satoshi Homma and Norio Ohshima},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={657}
}
Traditionally, autonomic cardiovasclar control has been attributed solely to adrenergic (sympathetic) and cholinergic (parasympathetic) neurotransmitters. It has recently been revealed that the cardiac and vascular tissues are also innervated by peptidergic neurons that may mediate nonadrenergic noncholinergic (NANC) functions. Among the neuropeptides, calcitonin gene-related peptide (CGRP) is of particular interest for the following reasons. First, it is expressed in a quite unusual way: an… 

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Calcitonin gene-related peptide regulates calcium current in heart muscle

TLDR
The results provide the first electrophysiological evidence that CGRP can significantly modulate I Ca in the heart, and suggest a new additional mechanism for the neurogenic control of cardiac function.

Systemic and Regional Hemodynamic Effects of Calcitonin Gene‐Related Peptide

TLDR
Systemic and regional hemodynamics were determined by the radioactive microsphere technique prior to and following the intravenous administration of 65-pmol and 2.2-nmoI doses of calcitonin gene-related peptide and vehicle to three groups of conscious, unrestrained rats.

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TLDR
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In addition to calcitonin and katacalcin, it is now known that the human calcitonin gene encodes a novel peptide called calcitonin gene related peptide (CGRP). In experimental animals, CGRP produces

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The role of calcitonin gene-related peptide (CGRP)-containing nerves in adrenergic vasoconstrictor response to periarterial nerve stimulation (PNS) was investigated in mesenteric vascular beds

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TLDR
It is indicated that CGRP is a potent vasodilator of mesenteric, renal and hindquarter skeletal muscle blood vessels in the conscious rat and its tachycardic effect seems to involve reflex activation of the sympathetic nervous system.

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TLDR
The results indicate that the cardiac effects of capsaicin may be due to the release of endogenous CGRP through a local mode of action, and argues against a role of prostaglandins or histamine in the functional responses of C GRP.

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TLDR
It is concluded that CGRP is a potent inhibitor of coronary artery vasomotor tone which appears to act directly on vascular smooth muscle rather than through the release of a secondary mediator.
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