Calcitonin Gene‐Related Peptide in the Regulation of Cardiac Function a

@article{Goto1992CalcitoninGP,
  title={Calcitonin Gene‐Related Peptide in the Regulation of Cardiac Function a},
  author={Katsutoshi Goto and Takashi Miyauchi and Satoshi Homma and Norio Ohshima},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={657}
}
Traditionally, autonomic cardiovasclar control has been attributed solely to adrenergic (sympathetic) and cholinergic (parasympathetic) neurotransmitters. It has recently been revealed that the cardiac and vascular tissues are also innervated by peptidergic neurons that may mediate nonadrenergic noncholinergic (NANC) functions. Among the neuropeptides, calcitonin gene-related peptide (CGRP) is of particular interest for the following reasons. First, it is expressed in a quite unusual way: an… 
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Dexamethasone and activators of the protein kinase A and C signal transduction pathways regulate neuronal calcitonin gene-related peptide expression and release

Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves

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Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart

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The blockade of TRPV4 can be considered as a new approach to the prevention of I/R injury of the heart because it has been documented that the activation of TRpV4 negatively affects the stability of cardiomyocytes to the H/R.

Expression of the genes for α-type and β-type calcitonin gene-related peptide during postnatal rat brain development

Advent of a New Generation of Antimigraine Medications

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The rationale and therapeutic implications of modulating CGRP, including its potential for acting at multiple sites in the trigeminovasculature, and the increasing evidence that antiepileptic drugs may be an effective prophylactic treatment for migraine are discussed.

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Innervation of the pineal gland in the Arctic fox (Vulpes lagopus) by nerve fibers immunoreactive to substance P and calcitonin gene-related peptide.

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The study demonstrates the presence of substance P (SP) and calcitonin gene-related peptide (CGRP) in the nerve fibers supplying the pineal gland in the Arctic fox and suggests that these peptides can regulate/modulate melatonin secretion.

Clinical and Preclinical Rationale for CGRP‐Receptor Antagonists in the Treatment of Migraine

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Both intravenous olcegepant and oral telcagepant have been effective, safe, and well tolerated in phase I and II studies and are currently in phase III trials, and preliminary results are favorable.

Receptors mediating CGRP‐induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by hα CGRP8–37

TLDR
The antagonist affinity for hα C GRP8–37 in porcine coronary artery is consistent with a CGRP1 receptor, while the lack of hαCGRP8-37 antagonism in rat aorta could suggest either a CgrP receptor different from CGRp1 and CGR p2 type, or a non‐CGRp receptor.

Bioactive β‐bend structures for the antagonist hα CGRP8–37 at the CGRP1 receptor of the rat pulmonary artery

TLDR
Within hα CGRP8–37, the N‐ terminus is not essential for antagonism while the C‐terminus may interact directly with C GRP1 receptors in the rat pulmonary artery, and possible bioactive structures of h α CGRp8-37 include two β‐bends, which were mimicked by BTD incorporation.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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