Calcitonin—a Hormone from the Parathyroid which Lowers the Calcium-level of the Blood

  title={Calcitonin—a Hormone from the Parathyroid which Lowers the Calcium-level of the Blood},
  author={D. Harold Copp and B A Cheney},
CONTROL of the calcium-level in blood is the primary function of the parathyroids. McLean1 has suggested that this is accomplished through a ‘feedback’ mechanism, by which a low level of calcium in the blood stimulates the glands to produce parathyroid hormone which in turn mobilizes calcium from bone and restores the normal level. High levels of calcium are assumed to suppress production of this hormone. 
Calcitonin: the other thyroid hormone.
Its potent antiresorptive effect and analgesic action have led to its clinical use in treatment of Paget's bone disease, osteoporosis, and hypercalcemia of malignancy.
Role of calcitonin in the rapid minute‐to‐minute regulation of plasma Ca2+ homeostasis in the rat
Examination in vivo of the possible role of calcitonin (CT) in the very rapid, minute‐to‐minute regulation of plasma Ca2+ in rats found it to be a potential player in the regulation of calcium homeostasis.
Calcitonin, the forgotten hormone: does it deserve to be forgotten?
A precise role for calcitonin remains elusive more than 50 years after its discovery as it has an immediate effect on decreasing osteoclast activity and has been used for treatment of hypercalcemia.
Association of Human Serum Parathormone-like Activity with Pre-albumin Electrophoretic Zones
It is reported that, by ethanol fractionation of plasma, parathyroid hormone-like activity could be found in fractions II and III, the β and γ fractions.
Physiology of Calcium Homeostasis: An Overview.
Daily acquisition of calcium depends on the hormonally regulated state of calcium homeostasis through three main mechanisms: bone turnover, intestinal absorption, and renal reabsorption.
The Activity of Peptides of the Calcitonin Family in Bone.
Surprisingly, studies in genetically modified mice have demonstrated that the physiological role of calcitonin appears to be the inhibition of osteoblast activity and bone turnover, whereas amylin inhibits osteoclast activity.
Effects of calcitonin and parathyroid hormone on the regulation of cabindin‐D9k in the uterus, placenta, and fetal membrane of rats related to blood calcium level during late gestation
The results suggest that major alterations in calcium metabolism caused by maternal thyroparathyroidectomy (TPTX), are sufficient to affect the changes in reproductive tissues during late pregnancy.
Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.
Key aspects of the synthesis and structure of calcitonin, its cellular and molecular actions, and its therapeutic uses as they have emerged over the 40 years since its discovery are retraced.
Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations
The recent research studies carried out on genetically modified mice showed the inhibition of osteoclast activity by amylin, while astonishingly calcitonin plays its role by suppressing osteoblast and bone turnover.
Calcitonin: Its Physiological Role and Emerging Therapeutics
Calcitonin was discovered more than 40 years ago as a hormone that lowers circulating calcium levels [14, 15]. In mammals, the major site of calcitonin synthesis is the parafollicular cells of the


Direct Humoral Control of Parathyroid Function in the Dog.∗ †
  • D. Copp, A. Davidson
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1961
A “feedback” mechanism involving the parathyroids which is sufficiently sensitive and fast-acting to account for the acute homeostatic control of blood calcium is indicated.
The parathyroid hormone apparently regulates the level of calcium ions, and there is considerable circumstantial evidence that the stimulus is phosphorus metabolism, which is dependent on the preceding changes in the metabolism of phosphorus.