Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.

@article{Fox2001CalcineurinRS,
  title={Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.},
  author={Deborah S. Fox and Mara Cristina Pess{\^o}a da Cruz and Rey A.L. Sia and Hengming Ke and Gary Matthew Cox and Maria Elena Cardenas and Joseph Heitman},
  journal={Molecular microbiology},
  year={2001},
  volume={39 4},
  pages={835-49}
}
Calcineurin is a Ca2+-calmodulin-regulated protein phosphatase that is the target of the immunosuppressive drugs cyclosporin A and FK506. Calcineurin is a heterodimer composed of a catalytic A and a regulatory B subunit. In previous studies, the calcineurin A homologue was identified and shown to be required for growth at 37 degrees C and hence for virulence of the pathogenic fungus Cryptococcus neoformans. Here, we identify the gene encoding the calcineurin B regulatory subunit and demonstrate… CONTINUE READING