Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4

@article{Baksh2000CalcineurinRO,
  title={Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4},
  author={Shairaz Baksh and James A. DeCaprio and Steven J. Burakoff},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={2820-2827}
}
Cyclin dependent kinase 4 (cdk4) activity is controlled by the binding of regulatory subunits and inhibitory factors, as well as tyrosine and serine/threonine phosphorylation. More recently the influence of calcium levels have been demonstrated. Using transient transfections in Jurkat cells, we observed specific binding between cdk4 and the calcium and calmodulin activated serine/threonine phosphatase, calcineurin. Furthermore, we demonstrated that the inhibition of the phosphatase activity of… CONTINUE READING
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Showing 1-5 of 5 references

Nature, 392, 303 ± 306

  • T. Miyakawa
  • Mondragon A, Grith EC, Sun L, Xiong F, Armstrong…
  • 1998

Annu

  • A Rao, C Luo, PG. Hogan
  • Rev. Immunol.,
  • 1997
1 Excerpt

J

  • ES Knudsen, Wang JY.
  • Biol. Chem., 271, 8313 ± 8320.
  • 1996

Mol

  • CJ, Kato JY.
  • Cell. Biol., 14, 2066 ± 2076. Mizunuma M, Hirata…
  • 1994

Nature, 227, 680 ± 685

  • Laemmli UK.
  • Matsushime H, Quelle DE, Shurtle€ SA, Shibuya M…
  • 1970

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