Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart.

  title={Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart.},
  author={Arun Bandyopadhyay and Dong-wook Shin and Jungoh Ahn and Do Han Kim},
  journal={The Biochemical journal},
  volume={352 Pt 1},
The present study was undertaken to examine the physical and physiological interaction of protein phosphatase 2B, calcineurin, with the ryanodine receptor (RyR) in rat cardiac tissue and neonatal cardiomyocytes. The presence of calcineurin, the RyR and FK506-binding protein (FKBP)12.6 in rat cardiac sarcoplasmic reticulum (SR) was identified by Western blot analysis. The possible interactions between calcineurin, the RyR and FKBP12.6 were further studied by co-immunoprecipitation using CHAPS… CONTINUE READING
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