Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP.

@article{Kipanyula2012CalcineurinnuclearFO,
  title={Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP.},
  author={Maulilio John Kipanyula and Ashwin Woodhoo and Mary Rahman and Donna Payne and Kristjan R Jessen and Rhona Mirsky},
  journal={Journal of neuroscience research},
  year={2012},
  volume={91 1},
  pages={
          105-15
        }
}
The transcription factor Krox-20 (Egr2) is a master regulator of Schwann cell myelination. In mice from which calcineurin B had been excised in cells of the neural crest lineage, calcineurin-nuclear factor of activated T cells (NFAT) signaling was required for neuregulin-related Schwann cell myelination (Kao et al. [2009] Immunity 12:359-372). Whether NFAT signaling required simultaneous elevation of intracellular cAMP levels was not explored. In vivo, Krox-20 expression requires continuous… CONTINUE READING

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  • 2013
VIEW 6 EXCERPTS
CITES BACKGROUND
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  • 2018

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References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

and myelination in mammals

L Morgan, KR Jessen, R Mirsky
  • 1991
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL