Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.

Abstract

Y-box (YB) protein-1 serves as a master regulator in gene transcription and mRNA translation. YB-1 itself is regulated at various levels, e.g. through post-translational modifications. In our previous work, we identified RANTES/CCL5 as a transcriptional target of YB-1. We previously demonstrated that YB-1 protein is transiently up-regulated during monocyte… (More)
DOI: 10.1074/jbc.M114.562991

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@article{Alidousty2014CalcineurinmediatedYD, title={Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.}, author={Christina Alidousty and Thomas Rauen and Lydia Hanssen and Qiang Wang and Setareh Alampour-Rajabi and Peter R. Mertens and Juergen Bernhagen and Juergen Floege and Tammo Ostendorf and Ute Raffetseder}, journal={The Journal of biological chemistry}, year={2014}, volume={289 31}, pages={21401-12} }