Calcineurin is required for Candida albicans to survive calcium stress in serum.

@article{Blankenship2005CalcineurinIR,
  title={Calcineurin is required for Candida albicans to survive calcium stress in serum.},
  author={Jill R Blankenship and Joseph Heitman},
  journal={Infection and immunity},
  year={2005},
  volume={73 9},
  pages={5767-74}
}
The calcium-activated protein phosphatase calcineurin plays a critical role in the virulence of Candida albicans. Previous studies demonstrated that calcineurin is not required for the yeast-hypha dimorphic transition, host cell adherence, or host cell injury, which are all established virulence attributes of this organism. Calcineurin is, however, essential for survival in serum and disseminated infection. Here we identify the component of serum that is toxic to calcineurin mutant cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Stress Response Mechanisms in Fungi

Springer International Publishing • 2018

References

Publications referenced by this paper.
Showing 1-10 of 48 references

CALCINEURIN AND C. ALBICANS SURVIVAL IN SERUM 5773 on O cber 30, 2017 by gest http/iai.asm .rg/ D ow nladed fom

D. A. Hudson, Q. L. Sciascia, +3 authors VOL
Microbiology • 2005
View 1 Excerpt

Candida infections of medical devices

D. B. Louria
Clin . Microbiol . Rev . • 2004

Similar Papers

Loading similar papers…