Calcineurin is required for Candida albicans to survive calcium stress in serum.

  title={Calcineurin is required for Candida albicans to survive calcium stress in serum.},
  author={Jill R Blankenship and Joseph Heitman},
  journal={Infection and immunity},
  volume={73 9},
The calcium-activated protein phosphatase calcineurin plays a critical role in the virulence of Candida albicans. Previous studies demonstrated that calcineurin is not required for the yeast-hypha dimorphic transition, host cell adherence, or host cell injury, which are all established virulence attributes of this organism. Calcineurin is, however, essential for survival in serum and disseminated infection. Here we identify the component of serum that is toxic to calcineurin mutant cells… CONTINUE READING

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