Calcineurin is essential for Candida albicans survival in serum and virulence.

  title={Calcineurin is essential for Candida albicans survival in serum and virulence.},
  author={Jill R Blankenship and Floyd L Wormley and Molly K Boyce and Wiley A. Schell and Scott G. Filler and John R Perfect and Joseph Heitman},
  journal={Eukaryotic cell},
  volume={2 3},
Calcineurin is a calcium-activated protein phosphatase that is the target of the immunosuppressants cyclosporin A and FK506. In T cells, calcineurin controls nuclear import of the NF-AT transcription factor and gene activation. In plants and fungi, calcineurin functions in stress responses (e.g., temperature, cations, and pH) and is necessary for the virulence of the fungal pathogen Cryptococcus neoformans. Here we show that calcineurin is also required for the virulence of another major fungus… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 78 extracted citations


Publications referenced by this paper.
Showing 1-10 of 67 references

Ergos - terol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors in Candida albicans , Candida glabrata , and Candida kru

  • A. N. Ellepola
  • Antimicrob . Agents Chemother .
  • 2003

Similar Papers

Loading similar papers…