Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

  title={Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes},
  author={J. Liu and Jesse D. Farmer and Willam S. Lane and J. Friedman and S. Schreiber},
  • J. Liu, Jesse D. Farmer, +2 authors S. Schreiber
  • Published 1991
  • Biology, Medicine
  • Cell
  • Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their similar mechanisms of inhibition of cell signaling suggest that their associated immunophilin complexes interact with a common target. We report here that the complexes cyclophilin-CsA and FKBP-FK506 (but not cyclophilin, FKBP, FKBP-rapamycin, or FKBP-506BD) competitively bind to and inhibit the Ca(2+)- and calmodulin-dependent phosphatase calcineurin, although the… CONTINUE READING
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