Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

@article{Kontoyiannis2008CalcineurinIA,
  title={Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.},
  author={Dimitrios P Kontoyiannis and Russell E Lewis and Barbara Dudley Alexander and Olivier Lortholary and Françoise Dromer and Krishan Lal Gupta and George Tharayil John and Ramon del Busto and Goran B. G. Klintmalm and Jyoti Somani and Goteborg M. Lyon and Kenneth J Pursell and Valentina Stosor and Patricia Mu{\~n}oz and Ajit P Limaye and Andre C Kalil and Timothy L. Pruett and Julia B Garcia-Diaz and Atul Humar and Sally H Houston and Andrew Alan House and Dannah Wray and Susan L. Orloff and Lorraine A Dowdy and Robert A. Fisher and Joseph Heitman and Nathaniel D. Albert and Marilyn M. Wagener and Ningombam Heramani Singh},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 2},
  pages={
          735-8
        }
}
Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents. 

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