Calcineurin inhibition in splenocytes induced by pavlovian conditioning.

@article{PachecoLpez2009CalcineurinII,
  title={Calcineurin inhibition in splenocytes induced by pavlovian conditioning.},
  author={Gustavo Pacheco-L{\'o}pez and Carsten Riether and Raphael Aloise Doenlen and Harald Engler and Mari Niemi and Andrea Engler and Annemieke Kavelaars and Cobi J Heijnen and Manfred Schedlowski},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 4},
  pages={
          1161-7
        }
}
Pavlovian conditioning is one of the major neurobiological mechanisms of placebo effects, potentially influencing the course of specific diseases and the response to a pharmacological therapy, such as immunosuppression. In our study with behaviorally conditioned rats, a relevant taste (0.2% saccharin) preceded the application of the immunosuppressive drug cyclosporin A (CsA), a specific calcineurin (CaN) inhibitor. Our results demonstrate that through pavlovian conditioning the particular… CONTINUE READING
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