Calcineurin inhibition eliminates the normal inverted U curve, enhances acquisition and prolongs memory in a mammalian 3′-5′-cyclic AMP–dependent learning paradigm

@article{ChristieFougere2009CalcineurinIE,
  title={Calcineurin inhibition eliminates the normal inverted U curve, enhances acquisition and prolongs memory in a mammalian 3′-5′-cyclic AMP–dependent learning paradigm},
  author={Melissa M. Christie-Fougere and Andrea Darby-King and Carolyn W. Harley and John H. McLean},
  journal={Neuroscience},
  year={2009},
  volume={158},
  pages={1277-1283}
}
The role protein phosphatase 2B (calcineurin, CaN) plays in learning and memory has received a significant amount of attention due to its promotion of the dephosphorylation of 3'-5'-cyclic AMP response element binding protein (CREB). Researchers have ascertained that overexpression of CaN is associated with memory retention deficits [Foster TC, Sharrow KM, Masse JR, Norris CM, Kumar A (2001) Calcineurin links Ca(2+) dysregulation with brain aging. J Neurosci 21:4066-4073; Mansuy IM, Mayford M… CONTINUE READING

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