Calcineurin inhibition as therapy for cardiac hypertrophy and heart failure: requiescat in pace?

  • R A Walsh
  • Published 1999 in Circulation research


Congestive heart failure is a major public health problem that is increasing, despite a reduced incidence and prevalence of other forms of cardiovascular disease. Initially, the heart responds to diverse pathological stimuli by an increase in mass achieved principally by enlargement of terminally differentiated cardiomyocytes. The resulting augmented… (More)


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