Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation.

@article{Luo1999CalcineurinEA,
  title={Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation.},
  author={Z David Luo and Y Wang and Guy Werlen and Shelley Camp and Kenneth R. Chien and Patricia Taylor},
  journal={Molecular pharmacology},
  year={1999},
  volume={56 5},
  pages={886-94}
}
Treatment of C2-C12 mouse myoblasts with the immunosuppressant drug cyclosporin A (CsA) enhances the increase in acetylcholinesterase (AChE) expression observed during skeletal muscle differentiation. The enhanced AChE expression is due primarily to increased mRNA stability because CsA treatment increases the half-life of AChE mRNA, but not the apparent transcriptional rate of the gene. Neither tacrolimus (FK506), an immunosuppressive agent with a distinct structure, nor cyclosporine H, an… CONTINUE READING