Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p

  title={Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p},
  author={Ren{\'e}e S. Polizotto and Martha S. Cyert},
  journal={The Journal of Cell Biology},
  pages={951 - 960}
Calcineurin is a conserved Ca2+/calmodulin-specific serine-threonine protein phosphatase that mediates many Ca2+-dependent signaling events. In yeast, calcineurin dephosphorylates Crz1p, a transcription factor that binds to the calcineurin-dependent response element, a 24-bp promoter element. Calcineurin-dependent dephosphorylation of Crz1p alters Crz1p nuclear localization. This study examines the mechanism by which calcineurin regulates the nuclear localization of Crz1p in more detail. We… CONTINUE READING


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