Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

@article{Genazzani1999CalcineurinCI,
  title={Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.},
  author={Armando A Genazzani and Ernesto Carafoli and Danilo Guerini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 10},
  pages={5797-801}
}
In the central nervous system, release of Ca2+ from intracellular stores contributes to numerous functions, including neurotransmitter release and long-term potentiation and depression. We have investigated the developmental profile and the regulation of inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) in primary cultures of cerebellar granule cells. The expression of both receptor types increases during development. Whereas the expression of type 1 IP3R appears to be… CONTINUE READING