Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma.

@article{Huang2005CalcineurinCI,
  title={Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma.},
  author={Wei Huang and John B. Fileta and Adam Dobberfuhl and Theodoros Filippopolous and Yan Guo and Gina P. Kwon and Cynthia L. Grosskreutz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 34},
  pages={
          12242-7
        }
}
Increased intraocular pressure (IOP) leads, by an unknown mechanism, to apoptotic retinal ganglion cell (RGC) death in glaucoma. We now report cleavage of the autoinhibitory domain of the protein phosphatase calcineurin (CaN) in two rodent models of increased IOP. Cleaved CaN was not detected in rat or mouse eyes with normal IOP. In in vitro systems, this constitutively active cleaved form of CaN has been reported to lead to apoptosis via dephosphorylation of the proapoptotic Bcl-2 family… CONTINUE READING

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