Calcineurin-catalyzed reaction with phosphite and phosphate esters of tyrosine.

@article{Wang1991CalcineurincatalyzedRW,
  title={Calcineurin-catalyzed reaction with phosphite and phosphate esters of tyrosine.},
  author={H Wang and Donald J. Graves},
  journal={Biochemistry},
  year={1991},
  volume={30 12},
  pages={3019-24}
}
A convenient synthesis is reported for the preparation of the phosphite ester of tyrosine methyl ester. By use of calcineurin, at 30 degrees C, a phosphite ester was hydrolyzed with a VM value [119 nmol/(min.micrograms of E)] approximately 500 times greater than that obtained with tyrosine phosphate [0.23 nmol/(min.microgram of E)] as substrate, but with… CONTINUE READING