Calcineurin and NFAT4 induce chondrogenesis.

  title={Calcineurin and NFAT4 induce chondrogenesis.},
  author={Masuhiro Tomita and Martina I. Reinhold and Jeffery D Molkentin and Michael C. Naski},
  journal={The Journal of biological chemistry},
  volume={277 44},
Nuclear factor of activated T-cells (NFAT) and calcineurin are essential regulators of immune cell and mesenchymal cell differentiation. Here we show that elevated intracellular calcium induces chondrogenesis through a calcineurin/NFAT signaling axis that activates bone morphogenetic protein (BMP) expression. The calcium ionophore, ionomycin, induced chondrogenesis through activation of calcineurin. The calcineurin substrate, NFAT4, also induced chondrogenesis and chondrocyte gene expression… CONTINUE READING