Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients.

@article{Batiuk1995CalcineurinAI,
  title={Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients.},
  author={Thomas D Batiuk and Feldzgeritta Pazderka and Philip F. Halloran},
  journal={Transplantation},
  year={1995},
  volume={59 10},
  pages={1400-4}
}
Measurement of the degree of immunosuppression induced clinically by drugs such as cyclosporine is an important but elusive goal. In lymphocytes in vitro, cyclosporine (CsA) blocks the phosphatase activity of the enzyme calcineurin, preventing cytokine induction. We sought to measure the degree of calcineurin blockade in patients on CsA. Calcineurin activity was measured in peripheral blood mononuclear cells (PBL) from stable CsA-treated renal transplant patients, compared with controls… CONTINUE READING
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