Calcineurin Inhibitors Suppress Cytokine Production from Memory T Cells and Differentiation of Naïve T Cells into Cytokine-Producing Mature T Cells

@inproceedings{Tsuda2012CalcineurinIS,
  title={Calcineurin Inhibitors Suppress Cytokine Production from Memory T Cells and Differentiation of Na{\"i}ve T Cells into Cytokine-Producing Mature T Cells},
  author={Kenshiro Tsuda and Keiichi Yamanaka and Hiroshi Kitagawa and Tomoko Akeda and Masanao Naka and Kaori Niwa and Takehisa Nakanishi and Masato Kakeda and Esteban C Gabazza and Hitoshi Mizutani},
  booktitle={PloS one},
  year={2012}
}
T cells have been classified as belonging to the Th1 or Th2 subsets according to the production of defining cytokines such as IFN-γ and IL-4. The discovery of the Th17 lineage and regulatory T cells shifted the simple concept of the Th1/Th2 balance into a 4-way mechanistic pathway of local and systemic immunological activity. Clinically, the blockage of cytokine signals or non-specific suppression of cytokine predominance by immunosuppressants is the first-line treatment for inflammatory T cell… CONTINUE READING
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