• DOI:10.1038/nature05097
Corpus ID: 4397036

Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

@article{Heit2006CalcineurinNFATSR,
  title={Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function},
  author={J. Heit and {\AA}sa A. Apelqvist and X. Gu and M. Winslow and J. Neilson and G. Crabtree and S. Kim},
  journal={Nature},
  year={2006},
  volume={443},
  pages={345-349}
}

J. Heit, Åsa A. Apelqvist, +4 authors S. Kim

Published 2006

Biology

Nature

The growth and function of organs such as pancreatic islets adapt to meet physiological challenges and maintain metabolic balance, but the mechanisms controlling these facultative responses are unclear. Diabetes in patients treated with calcineurin inhibitors such as cyclosporin A indicates that calcineurin/nuclear factor of activated T-cells (NFAT) signalling might control adaptive islet responses, but the roles of this pathway in β-cells in vivo are not understood. Here we show that mice with… CONTINUE READING

View on Springer

Save to Library

Create Alert

Cite

Launch Research Feed