Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

  title={Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function},
  author={J. Heit and {\AA}sa A. Apelqvist and X. Gu and M. Winslow and J. Neilson and G. Crabtree and S. Kim},
  • J. Heit, Åsa A. Apelqvist, +4 authors S. Kim
  • Published 2006
  • Biology
  • Nature
  • The growth and function of organs such as pancreatic islets adapt to meet physiological challenges and maintain metabolic balance, but the mechanisms controlling these facultative responses are unclear. Diabetes in patients treated with calcineurin inhibitors such as cyclosporin A indicates that calcineurin/nuclear factor of activated T-cells (NFAT) signalling might control adaptive islet responses, but the roles of this pathway in β-cells in vivo are not understood. Here we show that mice with… CONTINUE READING
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