Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

@article{Heit2006CalcineurinNFATSR,
  title={Calcineurin/NFAT signalling regulates pancreatic $\beta$-cell growth and function},
  author={Jeremy J. Heit and {\AA}sa A. Apelqvist and Xueying Gu and Monte M. Winslow and Joel R Neilson and Gerald R. Crabtree and Seung K. Kim},
  journal={Nature},
  year={2006},
  volume={443},
  pages={345-349}
}
The growth and function of organs such as pancreatic islets adapt to meet physiological challenges and maintain metabolic balance, but the mechanisms controlling these facultative responses are unclear. Diabetes in patients treated with calcineurin inhibitors such as cyclosporin A indicates that calcineurin/nuclear factor of activated T-cells (NFAT) signalling might control adaptive islet responses, but the roles of this pathway in β-cells in vivo are not understood. Here we show that mice with… 
Transgenic Overexpression of Active Calcineurin in β-Cells Results in Decreased β-Cell Mass and Hyperglycemia
TLDR
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Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function
TLDR
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Calcineurin/NFAT signaling in the β‐cell: From diabetes to new therapeutics
  • J. Heit
  • Biology, Medicine
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
TLDR
Recent advances in the understanding of calcineurin and NFAT signaling in the β‐cell are reviewed and novel therapeutic approaches for the treatment of diabetes are discussed.
Calcineurin Signaling Regulates Human Islet β-Cell Survival*
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Findings reveal calcineurin as a regulator of human β-cell survival in part through regulation of Irs2, with implications for the pathogenesis and treatment of diabetes following organ transplantation.
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TLDR
An engraftment strategy to examine age-associated human islet cell replication competence and reveal mechanisms underlying age-dependent decline of β cell proliferation in human islets finds that exendin-4 (Ex-4), an agonist of the glucagon-like peptide 1 receptor (GLP-1R), stimulates human βcell proliferation in juvenile but not adult islets.
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Role of adenosine signalling and metabolism in β-cell regeneration.
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