Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.

  title={Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.},
  author={Jeremy J Heit and Asa A Apelqvist and Xueying Gu and Monte M Winslow and Joel R Neilson and Gerald R Crabtree and Seung Kyung Kim},
  volume={443 7109},
The growth and function of organs such as pancreatic islets adapt to meet physiological challenges and maintain metabolic balance, but the mechanisms controlling these facultative responses are unclear. Diabetes in patients treated with calcineurin inhibitors such as cyclosporin A indicates that calcineurin/nuclear factor of activated T-cells (NFAT) signalling might control adaptive islet responses, but the roles of this pathway in beta-cells in vivo are not understood. Here we show that mice… CONTINUE READING
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