Calcineurin/NFAT signaling in the β‐cell: From diabetes to new therapeutics

  title={Calcineurin/NFAT signaling in the β‐cell: From diabetes to new therapeutics},
  author={J. Heit},
  • J. Heit
  • Published 2007
  • Biology, Medicine
  • BioEssays
  • Pancreatic β‐cells in the islet of Langerhans produce the hormone insulin, which maintains blood glucose homeostasis. Perturbations in β‐cell function may lead to impairment of insulin production and secretion and the onset of diabetes mellitus. Several essential β‐cell factors have been identified that are required for normal β‐cell function, including six genes that when mutated give rise to inherited forms of diabetes known as Maturity Onset Diabetes of the Young (MODY). However, the… CONTINUE READING
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