Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.

@article{Bandyopadhyay2002CalcineurinAC,
  title={Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.},
  author={Jaya Bandyopadhyay and Jiyeon Lee and Jungsoo Lee and Jin Il Lee and Jae-Ran Yu and Changhoon Jee and Jeong-Hoon Cho and Sunki Jung and Myon Hee Lee and Sonia Zannoni and Andrew Singson and Do Han Kim and Hyeon-Sook Koo and J. Ahnn},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 9},
  pages={
          3281-93
        }
}
Calcineurin is a Ca(2+)-calmodulin-dependent serine/threonine protein phosphatase that has been implicated in various signaling pathways. Here we report the identification and characterization of calcineurin genes in Caenorhabditis elegans (cna-1 and cnb-1), which share high homology with Drosophila and mammalian calcineurin genes. C. elegans calcineurin binds calcium and functions as a heterodimeric protein phosphatase establishing its biochemical conservation in the nematode. Calcineurin is… CONTINUE READING