Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.

@article{Mizobuchi2004CalcimimeticCU,
  title={Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.},
  author={Masahide Mizobuchi and Ikuji Hatamura and Hiroaki Ogata and Fumie Saji and Susumu Uda and Kazuhiro Shiizaki and Toshifumi Sakaguchi and Shigeo Negi and Eriko Kinugasa and Shozo Koshikawa and Tadao Akizawa},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 10},
  pages={2579-87}
}
The reduced expression level of the calcium-sensing receptor (CaR) is attributed to the hyposensitivity of parathyroid cells to extracellular calcium concentration [Ca2+]o, which plays a crucial role in the pathogenesis of secondary hyperparathyroidism (SHPT) in patients and rats with chronic renal insufficiency (CRI). Calcimimetic compounds have been demonstrated to improve the decreased sensitivity of CaR to extracellular calcium concentration and to suppress both parathyroid hormone (PTH… CONTINUE READING