Calcifying disorders of the skin.

  title={Calcifying disorders of the skin.},
  author={John S Walsh and Janet A. Fairley},
  journal={Journal of the American Academy of Dermatology},
  volume={33 5 Pt 1},
  pages={693-706; quiz 707-10}
Calcium is vital to many biologic processes. In skin, it has a profound effect on keratinocyte proliferation, differentiation, and cell-cell adhesion. Serum calcium is tightly regulated by parathyroid hormone and 1,25(OH)2D3. Despite this careful regulation, calcification and ossification of cutaneous and subcutaneous tissues may occur. Cutaneous calcification may be divided into four major categories: dystrophic, metastatic, idiopathic, and iatrogenic. Dystrophic calcification occurs as a… CONTINUE READING
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