Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin.

  title={Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin.},
  author={Tetsunari Wada and Marc D McKee and Susan A Steitz and Cecilia M. Giachelli},
  journal={Circulation research},
  volume={84 2},
Calcification of vascular tissue is a common complication in aging, atherosclerosis, diabetes, renal failure, aortic stenosis, and prosthetic valve replacement. Osteopontin is a noncollagenous adhesive protein routinely found at sites of dystrophic calcification and synthesized at high levels by macrophages in calcified aortic valves and atherosclerotic plaques. In the present study, we have characterized the calcification of bovine aortic smooth muscle cell (BASMC) cultures in vitro and have… CONTINUE READING


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Osteopontin is associated with bioprosthetic heart valve calcification in humans.

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