Calcification of medial elastic fibers and aortic elasticity.

  title={Calcification of medial elastic fibers and aortic elasticity.},
  author={Nathalie Niederhoffer and Isabelle Lartaud-Idjouadiene and Philippe Giummelly and Claude Duvivier and Ren{\'e} Peslin and Jeffrey Atkinson},
  volume={29 4},
We tested the hypothesis that a simple change in wall composition (medial calcium overload of elastic fibers) can decrease aortic elasticity. Calcium overload was produced by hypervitaminosis D plus nicotine (VDN) in the young rat. Two months later, measurement of central aortic mean blood pressure in the unanesthetized, unrestrained rat showed that the VDN rat suffered from isolated systolic hypertension but that mean blood pressure was normal. Wall thickness and internal diameter determined… CONTINUE READING


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