Calcification of bicuspid aortic valves.

  title={Calcification of bicuspid aortic valves.},
  author={Catherine M. Otto},
  volume={88 4},
Over the past decade, our concept of the pathogenesis of calcific aortic valve disease has undergone a major transformation. We now recognise that calcific valve disease is the end stage of an active disease process and is not caused by “wear and tear” of the valve tissue. Immunohistochemical studies of trileaflet aortic valves with varying degrees of valve stenosis have demonstrated the presence of inflammation, lipid infiltration, and production of proteins that mediate tissue calcification… CONTINUE READING
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