Calcifediol to treat secondary hyperparathyroidism in patients with chronic kidney disease.

@article{Galassi2017CalcifediolTT,
  title={Calcifediol to treat secondary hyperparathyroidism in patients with chronic kidney disease.},
  author={Andrea Galassi and Antonio Bellasi and Paola Ciceri and Francesca Pivari and Ferruccio Conte and Mario Gennaro Cozzolino},
  journal={Expert review of clinical pharmacology},
  year={2017},
  volume={10 10},
  pages={
          1073-1084
        }
}
INTRODUCTION Deranged vitamin D metabolism represents an active trigger of secondary hyperparathyroidism (SHPT) in CKD. Correction of 25(OH)D deficiency by nutritional Vitamin D administration is suggested by KDIGO guidelines, to prevent and treat SHPT in CKD stage G3-G5 and G1T-G5T patients, although with a still inconsistent background. Nutritional vitamin D is available as cholecalciferol, ergocalciferol, or calcifediol. Superiority of calcifediol in increasing 25(OH)D levels has been… CONTINUE READING

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Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Expert commentary : although optimal targets of 25(OH)D and parathormone remain uncertain , calcifediol , especially in its newer MR formulation , may represent an intriguing option to combine an efficacious correction of 25(OH)D deficit and SHPT , with a limited impact on vitamin D catabolism and FGF-23 activation .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
The safer pharmacokinetic of the recent modified - release ( MR ) formulation of calcifediol was effective in replenishing 25(OH)D levels with minimal impact on vitamin D catabolism and fibroblast - growth factor-23 ( FGF-23 ) activation .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Vitamin DChemical structure ofCholecalciferol
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Nutritional vitamin D is available as cholecalciferol , ergocalciferol , or calcifediol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
Areas covered : the review discusses utility of calcifediol for treating SHPT in different CKD stages under physiology driven approach , focusing on vitamin D metabolism , guidelines suggestions and comparison between clinical effects on SHPT elicited by calcifediol , cholecalciferol and ergocalciferol .
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