Calcemic and phosphaturic response to parathyroid hormone in normal and chronically uremic dogs.

@article{Jacob1982CalcemicAP,
  title={Calcemic and phosphaturic response to parathyroid hormone in normal and chronically uremic dogs.},
  author={A I Jacob and G Gavellas and J M Canterbury and Jacques J. Bourgoignie},
  journal={Kidney international},
  year={1982},
  volume={22 1},
  pages={21-6}
}
It is well established that the calcemic response to parathyroid hormone (PTH) is blunted in chronic uremia and is corrected partially by 1,25(OH)2D treatment. Recent evidence suggests that PTH(1-34) and not PTH(1-84) may be the actual calcemic fragment. Equivalent doses of both peptides were infused into five normal dogs (GFR = 51 ml/min) and eight dogs with a remnant kidney and chronic renal insufficiency (GFR = 15 ml/min). Both the calcemic and phosphaturic responses were studied. Remnant… CONTINUE READING