Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination.

@article{Barski2003CalbindinIC,
  title={Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination.},
  author={Jaroslaw Jerzy Barski and Jana Hartmann and Christine R Rose and Freek E Hoebeek and Karin M{\"o}rl and Michael Noll-Hussong and Chris I De Zeeuw and Arthur Konnerth and Michael M. Meyer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 8},
  pages={
          3469-77
        }
}
Long-term depression (LTD) of Purkinje cell-parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of the metabotropic glutamate receptor-IP3-calcium signaling cascade in mutant mice results in severe deficits of both synaptic transmission and cerebellar motor control. Here, we demonstrate that selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje… CONTINUE READING

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