Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment

@article{Whitney2008CalbindinD28kIA,
  title={Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment},
  author={E. R. Whitney and T. L. Kemper and D. Rosene and M. Bauman and G. Blatt},
  journal={Journal of Neuroscience Methods},
  year={2008},
  volume={168},
  pages={42-47}
}
  • E. R. Whitney, T. L. Kemper, +2 authors G. Blatt
  • Published 2008
  • Biology, Medicine
  • Journal of Neuroscience Methods
    • In a study of human Purkinje cell (PC) number, a striking mismatch between the number of PCs observed with the Nissl stain and the number of PCs immunopositive for calbindin-D28k (CB) was identified in 2 of the 10 brains examined. In the remaining eight brains this mismatch was not observed. Further, in these eight brains, analysis of CB immunostained sections counterstained with the Nissl stain revealed that more than 99% Nissl stained PCs were also immunopositive for CB. In contrast, in the… CONTINUE READING
    View on Elsevier
    bumc.bu.edu
    53 Citations
    Highly Influential Citations
    1
    Background Citations
    15
    Methods Citations
    8
    Results Citations
    2
    53 Citations
    Citation Type

    Citation Type

    Cerebellar Purkinje Cells are Reduced in a Subpopulation of Autistic Brains: A Stereological Experiment Using Calbindin-D28k
    • 210
    • PDF
    Topography of Purkinje Cells and Other Calbindin-Immunoreactive Cells Within Adult and Hatchling Turtle Cerebellum
    • 7
    Calbindin‐D28K Immunoreactivity in the Human Cerebellar Cortex
    • 13
    A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum.
    • 2
    Optimized immunohistochemical analysis of cerebellar purkinje cells using a specific biomarker, calbindin d28k.
    • B. Kim, S. Lee, +5 authors J. Jeon
    • Medicine
    • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
    • 2009
    • 13
    • PDF
    Types and density of calbindin D28k-immunoreactive ganglion cells in mouse retina.
    • 6
    Subsurface cistern (SSC) proliferation in Purkinje cells of the rat cerebellum in response to acute and chronic exposure to paint thinner: A light and electron microscopy study.
    • 3
    Altered microglia and neurovasculature in the Alzheimer's disease cerebellum
    • 6
    Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions
    • 2
    • PDF
    Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
    • 6

    References

    SHOWING 1-10 OF 25 REFERENCES
    Fractionator studies on Purkinje cells in the human cerebellum: numbers in right and left halves of male and female brains.
    • 15
    Calcium-binding proteins in primate cerebellum
    • 66
    • Highly Influential
    Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus.
    • 237
    Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • 2,837
    MRI Atlas of the Human Cerebellum
    • 538
    Acute Hypoxia‐Induced Alterations of Calbindin‐D28k Immunoreactivity in Cerebellar Purkinje Cells of the Guinea Pig Fetus at Term
    • 25
    • PDF
    Greenfield's Neuropathology
    • 258
    • PDF
    On the number of purkinje cells in the human cerebellum: Unbiased estimates obtained by using the “fractionator”
    • 37
    A cryoprotection method that facilitates cutting frozen sections of whole monkey brains for histological and histochemical processing without freezing artifact.
    • D. Rosene, N. Roy, B. Davis
    • Chemistry, Medicine
    • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    • 1986
    • 337
    Greenfield's Neuropathology
    • 1,195
    • PDF