Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment
@article{Whitney2008CalbindinD28kIA,
title={Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment},
author={Elizabeth R. Whitney and Thomas L. Kemper and Douglas L. Rosene and Margaret L. Bauman and Gene J. Blatt},
journal={Journal of Neuroscience Methods},
year={2008},
volume={168},
pages={42-47}
}
56 Citations
Cerebellar Purkinje Cells are Reduced in a Subpopulation of Autistic Brains: A Stereological Experiment Using Calbindin-D28k
- BiologyThe Cerebellum
- 2008
It is demonstrated that a reduction in cerebellar PCs was not a consistent feature of these autistic brains and that it occurred without discernible correlation between their density and the clinical features or severity of autism.
Topography of Purkinje Cells and Other Calbindin-Immunoreactive Cells Within Adult and Hatchling Turtle Cerebellum
- BiologyThe Cerebellum
- 2009
It is suggested that unique physiological features may exist along the rim of the turtle Cb, including new neurons being generated within the adult and hatchling Cb and if they connect to efferent and afferent paths.
Calbindin‐D28K Immunoreactivity in the Human Cerebellar Cortex
- BiologyAnatomical record
- 2014
It is reported that CB is expressed by different neuron types, both inhibitory (GABAergic) and excitatory (glutamatergic), involved in both intrinsic and extrinsic circuits of the human cerebellar cortex.
A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum.
- BiologyCancer genomics & proteomics
- 2016
Since MPS1 is involved in cell division, DNA repair, and ribosomal biogenesis, it may be a useful antigen for studying processes such as protein synthesis, oncogenesis, regeneration, aging, and perhaps diseases of the human cerebellum.
Optimized immunohistochemical analysis of cerebellar purkinje cells using a specific biomarker, calbindin d28k.
- BiologyThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
- 2009
An optimized and validated IHC method using antibodies to calbindin D28k, a specific PC marker in the cerebellum is presented and it is demonstrated that dye filtration using a 0.22 microm filter eliminates or minimizes nonspecific staining while preserving the analytical sensitivity.
Subsurface cistern (SSC) proliferation in Purkinje cells of the rat cerebellum in response to acute and chronic exposure to paint thinner: A light and electron microscopy study.
- BiologyExperimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- 2014
Altered microglia and neurovasculature in the Alzheimer's disease cerebellum
- BiologyNeurobiology of Disease
- 2019
Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions
- BiologyPloS one
- 2019
The results suggest that EFA6C plays ancillary roles in cerebellar development and motor functions.
Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
- BiologyCell transplantation
- 2017
Results indicate that intracranial hOEC transplantation has potential value as a novel strategy for treating SCA3, and the protein levels of tryptophan hydroxylase 2, the rate-limiting enzyme for serotonin synthesis in the cerebellum, and ryanodine receptor (RYR) increased in mice that received intrac Ranodine receptors transplantation.
Basic quantitative morphological methods applied to the central nervous system
- BiologyThe Journal of comparative neurology
- 2020
This review provides a refresher of problems associated with generating numbers that describe the nervous system in terms of the volumes, surfaces, lengths, and numbers of its components and describes the methods that address these problems.
References
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