Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.

@article{Lambers2006CalbindinD28KDC,
  title={Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.},
  author={Tim T. Lambers and Frank Mahieu and Elena Oancea and Louis J. C. Hoofd and Frank de Lange and Arjen R Mensenkamp and Thomas Voets and Bernd Nilius and David E Clapham and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={The EMBO journal},
  year={2006},
  volume={25 13},
  pages={
          2978-88
        }
}
In Ca(2+)-transporting epithelia, calbindin-D(28K) (CaBP(28K)) facilitates Ca(2+) diffusion from the luminal Ca(2+) entry side of the cell to the basolateral side, where Ca(2+) is extruded into the extracellular compartment. Simultaneously, CaBP(28K) provides protection against toxic high Ca(2+) levels by buffering the cytosolic Ca(2+) concentration ([Ca(2+)](i)) during high Ca(2+) influx. CaBP(28K) consistently colocalizes with the epithelial Ca(2+) channel TRPV5, which constitutes the apical… CONTINUE READING
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